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This review addresses the concept that sex differences in PD are determined, largely, by biological sex differences in the NSDA system which, in turn, arise from hormonal, genetic and environmental influences. Current therapies for PD rely on dopamine replacement strategies to treat symptoms, and there is an urgent, unmet need for disease modifying agents. As a significant degree of neuroprotection against the early stages of clinical or experimental PD is seen, respectively, in human and rodent females compared with males, a better understanding of brain sex dimorphisms in the intact and injured NSDA system will shed light on mechanisms which have the potential to delay, or even halt, the progression of PD. Available evidence suggests that sex-specific, hormone-based therapeutic agents hold particular promise for developing treatments with optimal efficacy in men and women. This, in turn, may be determined by biological sex differences in brain organisation, structure and function, which are determined genetically and epigenetically Gabory et al. PD is the second most common neurodegenerative disorder, affecting approximately 0. In addition, such figures highlight the increasing burden that treatment of PD place on health care systems worldwide, as the population life-expectancy increases in several countries.
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